Researchers Find New Alzheimer’s Disease Treatment Promising

Tuesday, July 14th, 2009 by Lockergnome at 9:56pm
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Researchers at Mount Sinai School of Medicine have found that a compound called NIC5-15 might be a safe and effective treatment to stabilize cognitive performance in patients with mild to moderate Alzheimer’s disease. The two investigators, Giulio Maria Pasinetti, M.D., Ph.D. , and Hillel Grossman, M.D., presented Phase IIA preliminary clinical findings at the Alzheimer’s Association 2009 International Conference on Alzheimer’s Disease (ICAD) in Vienna on Sunday, July 12.

NIC5-15’s potential to preserve cognitive performance will be further evaluated in a Phase IIB clinical trial. Early evidence suggests that NIC5-15 is a safe and tolerable natural compound that may reduce the progression of Alzheimer’s disease-related dementia by preventing the formation of beta-amyloid plaque, a waxy substance that accumulates between brain cells and impacts cognitive function.

“With Alzheimer’s disease affecting 5.2 million Americans, another 5 million with early-state disease, and nearly a half million new cases reported annually, treatments like NIC5-15 would make a significant difference in the lives of many Alzheimer’s patients,” said Dr. Pasinetti, Professor of Psychiatry, Professor of Neuroscience and Professor of Geriatrics and Adult Development, in the Department of Psychiatry at Mount Sinai School of Medicine. “We are hopeful that the follow up clinical study will support this preliminary evidence.”

“There are no FDA-approved Alzheimer’s disease modifying drugs available today,” said Dr. Hillel Grossman, Assistant Professor of Psychiatry, Co-Director of the Clinical Research Core of the Alzheimer’s Disease Research Center, and Clinical Director of the Mount Sinai Memory and Aging Center. “Current drugs approved for use help maintain cognitive function, but only for a limited time. NIC5-15 is part of a new class of natural compound we found to have the potential of precluding the generation of ?-amyloid and, eventually, attenuating cognitive deterioration in preclinical models of Alzheimer’s disease.”

[Mount Sinai Newsroom @ The Mount Sinai Hospital / Mount Sinai School of Medicine]

4 Comments

Can a Company Take Social Networking too Far? | Chris Pirillo

July 15th, 2009
at 5:25am

[...] Researchers are finding that new treatments for Alzheimer’s Disease are very promising. [...]

Can a Company Take Social Networking too Far? | dv8-designs

July 15th, 2009
at 6:46am

[...] Researchers are finding that new treatments for Alzheimer’s Disease are very promising. [...]

MerryMarjie

July 15th, 2009
at 11:55am

I can only hope a CURE or PREVENTION will happen with Alzheimer’s/Dementia. I lost my sister several years ago to this disease — she’s still alive, but she doesn’t know me or any of our family except the daughter she’s living with. She was so funny and cheerful, so bright, looks just like Betty White, and I love her so much, but she’s gone. It is so hard, people, to lose a loved one who has retreated into herself, who can no longer remember anything. Without our memories, who are we?